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First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

Herbal medicines offer multiple advantages, such as improving chemotherapy and targeted treatments, reducing the risk of metastasis and recurrence, extending patient survival, and enhancing overall quality of life

10.1038/s41413-024-00397-7 23 DowdellJ.ErwinM.ChomaT.VaccaroA.IatridisJ.ChoS

Oller-Salvia, B., Kym, G

ROC analysis based on pathway scores revealed that pathways such as alanine, aspartate, and glutamate metabolism, inositol phosphate metabolism, and mitochondrial beta-oxidation of unsaturated fatty acids exhibited an AUC greater than 0.8 in the PBMC data (Table S16)

GLP-1 Receptor Agonists Semaglutide and tirzepatide are technically peptide-based therapeutics