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Keywords: Antioxidants, cerebral circulation, endothelial dysfunction, NRF2, oxidant stress, Protandim, reactive oxygen species, resistance arteries, salt, sodium, superoxide dismutase, vascular dysfunction, vasodilation INTRODUCTION Although oxidant stress has been implicated experimentally in a variety of human diseases including cardiovascular pathologies, clinical trials investigating oral antioxidant therapies in the prevention of morbidity and mortality have shown little-to-no benefit with antioxidant supplementation

[DOI] [PubMed] [Google Scholar] Winter AN, Ross EK, Daliparthi V, Sumner WA, Kirchhof DM, Manning E, Wilkins HM, Linseman DA (2017) A cystine-rich whey supplement (Immunocal()) provides neuroprotection from diverse oxidative stress-inducing agents in vitro by preserving cellular glutathione

Chiral derivatization and LCMS analysis of amino acids Chiral derivatization assay Immunoprecipitated peptides were digested into amino acids by leucine aminopeptidase (3.6 l, 0.5 U) in 100 l of buffer (5 mM MgCl 2 , 100 mM NH 4 HCO 3 , pH 7.9) at 37 C for 24 h

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Interestingly, ACSS2 expression promoted myelomatous tumorigenesis through stabilization of IRF4, an oncogenic protein controlling a wide variety of genes that are key for cellular growth, survival and metabolic processes [75, 76]