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Data availability The data that supports the generation of oligonucleotides used in this study are openly available in Zenodo.org at The molecular evolutionary relations, ligand tracing and tracking of defined sequences through successive selection rounds were performed using COMPAS software (AptalT GbmH, Planneg, Germany) 41,42

6 Structural studies have revealed that NBDHEX interacts with both GSTP1 and GSTM1 in a similar fashion, engaging with their aromatic side chains, particularly Tyr108 in GSTP1 and Tyr115 in GSTM2

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Dilute the sample with PBS or lysis buffer at a ratio of 1:9 (w:v) (e.g., add 900 L of buffer to 100 mg of feces)