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Over 26 weeks, including a dose-escalation period of up to 6 weeks, researchers observed mean percentage weight reductions of 6.0% to 10.8% across the cagrilintide dose groups compared to just 3.0% with placebo

Transcriptomic support is currently more limited and indirect, because the available single-cell RNA sequencing datasets in human severe AP are derived predominantly from peripheral blood immune cells and therefore reflect systemic inflammatory activation rather than pancreas-specific inter-organellar signaling within acinar cells (98)

Indeed, the promoter regions of the BnGSTFs include many cis -elements associated with abiotic and biotic stress responses

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Hum Mol Genet (2010) 19:420715