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The mitochondrial tricarboxylic acid (TCA) cycle promotes ferroptosis, primarily because cysteine serves not only as a substrate for glutathione (GSH) biosynthesisessential for GPX4 activitybut also modulates glutamine catabolism

doi: 10.1371/journal.pone.0171441 111

Cysteine S-conjugate -lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents