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That way, if youre going to intervene with testosterone replacement or thyroid hormone or statins or whateverI mean, statins are mitochondrial toxins

Although the biological mechanisms in terms of the effect on the brain and body are poorly understood, the molecular correlates of these effects operate through the major neurochemical system, amines (acetylcholine, dopamine, and serotonin) and the putative release of endogenous cannabinoids and endorphins, which may exert salutary effects on mood/anhedonia (Muzik and Diwadkar, 2019)

However, its role in the prevention of DNA mutation, inflammation, and cell apoptosis, especially in relation to cancer cells, is controversial

doi:10.1007/978-3-031-02257-9_16

I wouldnt claim a direct lineage necessarily, but perhaps this boss bears some similarity to Ciarans original concept

Alterations in energy/redox metabolism induced by mitochondrial and environmental toxins: a specific role for glucose-6-phosphate-dehydrogenase and the pentose phosphate pathway in paraquat toxicity