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Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane (51), is transported into the blood circulation through Ferroportin1 (FPN1) on the intestinal epithelial cell membrane, and is then converted to Fe 3+ by heparin (Hp) or ceruloplasmin (52)

These proteases include thrombin [141,142,143,144], factor Xa [141,145], enterokinase [146], human rhinovirus (HRV) 3C protease/PreScission Protease [147], and tobacco etch virus (TEV) protease [148]

doi: 10.1038/cddis.2016.63 109

Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H

Therefore, we speculate that the interstitial fibrosis observed in HUA mice is mainly correlated with noradrenaline associated vascular effect

Larsen AT, Melander SA, Sonne N, et al