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The resulting oxidative environment induces lipid peroxidation and DNA damage, while activating MAPK/NF-B signaling to promote amyloid precursor protein expression and impair A clearance

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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Snchez-Feliciano A, Herrera H, Charrow A, Barbieri JS

There are two main types: sliding hiatal hernias, which are the most common and closely tied to GERD, and para-oesophageal hernias, which are rarer but can become a medical emergency