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Hepatic injury due to traditional aqueous extracts of kava root in New Caledonia

The PPARGC1A (1XB7) was found to have hydrophobic, hydrogen, and unfavourable amino acid interactions with ALA 516, ARG 458, and GLY 489

This pre-phosphorylation is tied to the lower glycolytic conversion of phosphoenolpyruvate (PEP) to pyruvate through two phosphocarrier proteins (PtsI [EI] & PtsH [HPr-His])