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Accordingly, we observe that intake of GLP-1RAs is associated with lower circulating TMAO levels, thereby potentially moderating the adverse effect of TMAO on kidney function and suggesting a putative mechanism for these drugs that observed renoprotection in large pharmaceutical trials 25

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC) (vol 42, pg 3227, 2021)

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Furthermore, studies suggest that these alkaloids may also directly induce programmed cell death in neurons and glial cells via activation of the PPAR/NF-B/caspase-3-dependent apoptotic pathway, offering a novel explanation for their potential long-term or subacute neurotoxic effects [42]

This process occurs naturally when the olives mature, as well as artificially during the storage and processing of table olives [42]