key role of serine in glutathione transferase functions Frontiers Frontiers | The role and

Graham TE

Agents such as rapamycin or curcumin enhance autophagic flux, leading to the degradation of key anti-ferroptotic proteins such as GPX4

Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis

Another study showed that resveratrol induced SIRT1 expression and the expression of cyclin D1, cyclin-dependent kinase 4 (CDK4) and proliferating cell nuclear antigen (PCNA) to promote liver regeneration, thereby preventing acetaminophen-induced hepatotoxicity (Wang et al., 2015)

Supplementing glycine alone can increase glutathione by 20-30% [10]

This epigenetic pathway is further reinforced in Clec4e-mediated response, in which ATF3 inhibits the downstream NF-B/JNK pathway and reduces TNF- and CCL2 secretion (136)