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Notably, the levels of DNMTs and TETs are abnormal in the retina and its vascular system in diabetic rats, suggesting that DNA methylation may play a role in the pathogenesis of DR (Kowluru et al., 2016

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The optimized nanoparticles improved drug brain permeation, protected dopaminergic cells from toxin-induced damage, and modulated key signaling pathways by upregulating neuroprotective proteins and downregulating neurodegenerative markers, such as -synuclein and phosphorylated tau (149)