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Myogenesis is the biological process of muscle tissue formation and repair

Finally, dihydrolipoamide dehydrogenase activity in the glycine cleavage system (L protein) and in the -ketoacid dehydrogenase complexes (protein E3) catalyzes the conversion of the dihydrolipoyl moiety (reduced form) to the lipoyl moiety (oxidized form)

These findings suggest that AST protects dopaminergic neurons through suppression of ER stress and stabilization of the miR-7/SNCA regulatory loop, presenting a promising target for PD therapy ( In summary, AST demonstrates promising therapeutic potential in PD by targeting key pathological mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction

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doi: 10.1016/j.ccell.2022.02.003 114 AlahdalMZhangHHuangRSunWDengZDuanLet al