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Pirfenidone selectively downregulates the expression of TGF-1, PDGF, and other fibrosis-associated cytokines, and nintedanib is a tyrosine kinase inhibitor targeting the VEGF receptor, FGF receptor, and PDGF receptor

The kidney and the heart are one of the most energy-demanding organs in humans and this makes these organs vulnerable to ROS-induced damage (Sureshbabu et al