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This approach, which often involves applying a fraction of the standard dose, is designed to investigate the cellular or physiological responses without provoking the full-blown effects of the drug

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Oral preparations of Vitamin B12 may increase serum levels but many patients remain symptomatic until they use sublingual or vitamin B12 injections due to low cellular concentrations 6

Vindigni, Timothy L

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Ethics declarations The Ethics Committee of Kashan University of Medical Sciences approved the study protocol (Registration No