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In summary, schisandrin lignans appear to protect dopaminergic neurons by a combination of antioxidant, anti-excitotoxic, anti-inflammatory, and pro-autophagic mechanisms, making them interesting candidates for further neuroprotective research

For its second application, the FDA set a PDUFA date of May 14, 2024, but this was pushed back by three months after Ascendis filed a major amendment to the application

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Images were acquired using an LSM880 microscope equipped with Fast Airyscan (Carl Zeiss)

(Also, positive for MTHFR.) Diagnosis: Pernicious anemia/B12 deficiency

Information extracted from UniProtKB entries includes subcellular localization and sequence features (topological domains, variants, post-translational modifications, etc.)