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proposed a model to demonstrate that the levels of NAMPT and NAD+ in hippocampal neurons, particularly in CA1 neurons, decline during aging, leading to a decrease in SIRT1 activity and subsequent downregulation of Cask expression in the aged hippocampus

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They are approved in many countries for migraine prevention (flunarizine) and management of vestibular symptoms and prevention of motion sickness (cinnarizine)