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10.3390/bios12121116 715 YamamotoJ.MatsuiA.GanF.OuraM.AndoR.MatsudaT.et al (2021)

A wound-healing study testing gels with the extract at 1%, 2%, and 3% concentrations and found none of them irritated the skin

When you see 500 mg on a label, you should have total confidence that the number represents clean, active ingredients without hidden additives

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Mouse experiments have shown that knockdown of Bnc1 leads to downregulation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)/silent mating type information regulation 2 homolog 1 (SIRT1)/Forkhead Box O3 (FOXO3) signaling, which in turn leads to mitochondrial dysfunction, decreased mitochondrial membrane potential, elevated ROS production, and increased expression of cytochrome c (Cyt-c), resulting in spermatogonial apoptosis and the failure of sperm production [88]

Chiang CL, Chan KSK, Li H, Ng WT, Chow JCH, Choi HCW, et al