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Based on hospital protocol, the antidote (N-acetylcysteine, NAC, weight-based dosage) was administered in 8 out of 13 patients, sometimes at several time points

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Common injection sites include: Anterior, inferior, and posterior glenohumeral ligaments Middle glenohumeral ligament (MGHL) Posterior capsule (for posterior instability) Rotator interval region Long head of biceps anchor (if involved) By treating these areas, prolotherapy helps restore the biomechanical integrity of the joint capsule, thereby reducing: Pain Recurrent subluxation or dislocation Weakness Activity limitations Ideal Candidates for Prolotherapy Prolotherapy may be appropriate for patients who: Have residual instability or discomfort after a shoulder dislocation Show evidence of ligament laxity on physical exam Have failed to achieve stability through physical therapy alone Want to avoid surgery Have generalized ligamentous laxity or hypermobility (e.g., Ehlers-Danlos) It is often most effective in those with functional instability (ligament laxity) rather than mechanical instability from severe labral tears

There is interest among researchers in using IGF-1 DES as a potential treatment in hyperglycemia were it would have similar effects to insulin administration without the long-term side effects that can occur if too much insulin is used