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[34] [75] Based on reviews of neuroimaging studies involving BED-diagnosed participants, therapeutic neuroplasticity in dopaminergic and noradrenergic pathways from long-term use of lisdexamfetamine may be implicated in lasting improvements in the regulation of eating behaviors that are observed

BMC Pulm Med (2017) 17(1):5

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The relatively low AUC of 0.64 for patient/carrier comparisons likely reflects overlap in age distribution, with many carriers already within the disease onset window, Supplemental Information Fig