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14a and b)

Introduction Chronic kidney disease (CKD), affecting approximately 13% of the global population, represents a significant public health burden characterized by progressive loss of renal function ( Enterobacteriaceae and Streptococcus , and decreased beneficial taxa like Prevotella and Roseburia ( Faecalibacterium , Lachnoclostridium , Lactobacillaceae ) and suppressing pathogenic bacteria such as Clostridium innocuum , Enterobacteriales ( CKD is globally prevalent, with gut microbiota dysbiosis increasingly implicated in its pathogenesis

W.JoostenH.-J.SchaapP

doi: 10.1007/s12975-011-0126-9 108

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Importantly, the lack of T2 B cells indicated that Gclc is needed in the transition to MZB or their precursors