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Opioid analgesics exhibit pharmacodynamic complementarity, permitting reduced opioid dose

For example, too much folic acid can hide a Vitamin B12 deficiency, causing nerve damage if not managed right

doi: 10.1200/JCO.2005.02.8852 16 ChangGJRodriguez-BigasMASkibberJMMoyerVA

Supra-pharmacological concentration of capsaicin stimulates brown adipogenesis through induction of endoplasmic reticulum stress

Functions of vitamin B12 and folate Vitamin B12 (cobalamin) and folate (vitamin B9) are vitamins that serve important functions in the human body

To elute the target molecule from the affinity medium the interaction can be reversed, either specifically using a competitive ligand, or non-specifically, by changing the pH, ionic strength or polarity