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However, the altered tissue microenvironment characteristic of chronic metabolic and inflammatory diseases significantly impairs neutrophil function, resulting in aberrant responses and tissue damage

TRP channels as cellular sensors

The mice were randomly divided into four groups (each containing at least five mice): a natural aging group, a natural aging + FOXO4-DRI group, a D-Gal group, and a D-Gal + FOXO4-DRI group

The main hormones involved are estrogen and progesterone, which are present in various forms of hormonal contraceptives such as birth control pills, patches, and rings

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

The latest data show that approximately 15% of reproductive couples in the world have a problem with infertility (2)