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Peer-reviewed articles relevant to the topic, published from January 2008 to March 2025, were searched and retrieved from PubMed (encompassing MEDLINE) using identical MeSH keywords to form the Initial Set

Host genes associated with reactive species production are indicated

Several generations of mTORC1 inhibitors have been developed: rapamycin and derivatives (rapalogs), kinase inhibitors including sapanisertib (13), and bi-steric mTORC1-selective inhibitors (14)