Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: implications in dopamine cytotoxicity and pathogenesis of Parkinsons disease
When damaged mitochondria exceed the capacity of mitophagy and fusion mechanisms, cells ultimately succumb to apoptosis or necrosis under the dual assault of energy failure and persistent inflammation
Non radicals Hydrogen peroxide (H 2 O 2 ) H 2 O 2 is an important ROS molecule primarily produced intracellularly through enzymatic reactions, notably by NOX family enzymes which are key dedicated generators of ROS [71]
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We conclude that NAC protected against phosgene-induced lung injury by acting as an antioxidant by maintaining protective levels of glutathione, reducing both lipid peroxidation and production of arachidonic acid metabolites
