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These two ghrelin receptor complexes display pronounced outward displacements of TM6 cytoplasmic end (~8 , measured at C of H258 6.30 ), the hallmark of GPCR activation, and ~3 inward shift of cytoplasmic end of TM7 (measured at C of Y323 7.53 ) (Fig

Clinical research has extended these mechanistic observations into human models

[8] One such potential pathway involves the activation of phospholipase C (PLC), which researchers suggest may lead to the release of inositol triphosphate (IP3) and diacylglycerol (DAG)