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Conversely, genetic inhibition of autophagy (e.g., Atg7 knockdown) reduced apoptosis and preserved spermatogenesis, suggesting that excessive autophagy can be harmful to germ cells 42

& Bolognesi, A

However, the TRIP12-dependent K29-linked ubiquitylation of OTUD5 was partially decreased by UBR5 knockdown, whereas TRIP12-dependent increase of K48-linked chains was massively diminished by UBR5 knockdown (Fig

H.DoyleJ

2.9 Estimation of lipid peroxidation (LPO) Lipid peroxidation was assessed by determining MDA (a thiobarbituric acid reactive species: TBARS) spectrophotometrically following the method of Beuge and Aust [11]