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A.Sangi-HaghpeykarH.ShowalterL.ShopeC.HuM.BrownK.et al (2012)

Beyond this period, its potency can significantly diminish, making consistent efficacy less likely

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[27] Acute attacks can be provoked by exposure to drugs that induce heme biosynthesis in the liver, as well as certain drugs that induce the cytochrome P450 detoxification system, excessive alcohol consumption, caloric restriction, stress, infection, certain hormonal factors, and increased production of hepatic ALAS1 in addition to other environmental factors

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