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To confirm Andexxas clinical benefit AstraZeneca used data from the Phase IV ANNEXA-I study, which found that the drug could induce significantly better hemostasis in patients with acute intracranial bleeding than usual care

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Before binding to specific DNA locus antioxidant response elements (AREs), Nrf2 will heterodimerize with Maf or Jun proteins in the nucleus (259, 260)

PSAT1 elevates GPX4 stability by promoting -ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation, disrupting its binding to HSC70 and inhibiting autophagy-mediated degradation

This ratio did not change in the semaglutide group [10]

Limitations across studies include reliance on rodent models and short-term outcomes, limited cell-specific genetics and safety data, frequent use of bulk LC3-II/p62 without rigorous flux assays, and focus on single pathways despite crosstalk between mTOR/AMPK, ubiquitination, and mitophagy