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Similarly, DNMT1 knockdown promoted senescence and decreased differentiation potentials of MSCs at early passage, whereas DNMT1 overexpression has the opposite effect at late-passage MSCs, suggesting that RB preserves the proliferation and differentiation potential of MSCs by upregulating DNMT1 [65]

median MELD was 20 (6-40)

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Others might need additional supplementation based on their health profile