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The three ingredients with the strongest documented mechanisms for supporting melanin production in hair follicles are Bhringraj (which upregulates tyrosinase expression, the enzyme that synthesises melanin), Amla (which provides concentrated antioxidant protection to melanocytes and supports copper absorption for tyrosinase activity), and Mulethi (which contains glabridin, a compound that inhibits the enzyme responsible for melanin breakdown)

doi: 10.1016/j.bbrc.2008.09.128

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Epidemiological studies consistently show that the prevalence of ED in such patients is higher than that in the general population, indicating that immune-mediated skin diseases may significantly increase the risk of ED