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119 The most prominent action of many peptides (i.e., bombesin, thyrotropin-releasing hormone, CRF, neurotensin) on gastric lesions 120 - 128 which appears when applied within the specific hypothalamic and brain stem sites or into the cerebrospinal fluid, 128 requires a corresponding effect from periphery

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This is known as one of the strongest polar interactions, as well as one of the most common forces involved in proteinligand complexes formation 93,94