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Sochman, J., N-Acetylcysteine Somewhere Between Scylla and Charybdis

Glutaminolysis as a target for cancer therapy

doi:10.1161/circgenetics.113.000208

Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

for example, it protects membranes by maintaining the reduced state of both -tocopherol and zeaxanthin, it prevents the oxidative denaturation of proteins under stress conditions by protecting their thiol groups, and it serves as a substrate for both glutathione peroxidase and glutathione S -transferase

The authors concluded that "those with ASDs are affected by an imbalance between their anti-oxidative and oxidative stress systems, a condition which could be treated with glutathione supplementation"