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A spokesperson for ZYN told TMZ Sports: "The company is very grateful for the support of loyal consumers, but also encourages users to ensure that the products are not in the presence of minors under the age of 21." "This product is specifically marketed to nicotine users aged 21 and older as a better alternative to continued smoking and the use of other traditional tobacco products

While surveys show that large, traditional cigar use among youth is lower than that of cigarettes, it is not insubstantial, as the industry has argued

We found a significant increase in IL-1 and IL-6 mRNA expression in cells exposed to 10% CSE compared to control cells (Figure 4A)

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