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Sequential schedulingfor example, priming with ferroptosis inducers to activate antitumor immunity before introducing cuproptosis-targeted agentsmay be required to avoid premature immunosuppression and achieve true synergy

Moreover, PF exhibited a suppressive effect on apoptosis by attenuating mitochondrial membrane potential, promoting cytochrome c release, and counteracting the upregulation of caspase-3 and caspase-9 in the case of A 2535 induced PC12 cell damage (Li et al., 2014)

Furthermore, NAC prevented chondrocyte apoptosis and cartilage destruction in an experimentally induced rat model of RA [140]

doi:10.1093/ibd/izac015.026

A common medication for this condition is methylphenidate hydrochloride (MPH), which is associated with various adverse effects (67)

Autophagy upregulation is believed to be a powerful strategy to clear the protein aggregation and slow or prevent neurodegeneration