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Biochem Pharmacol (2011) 82(12):180721.10.1016/j.bcp.2011.07.093 164 WeinrebOAmitTMandelSYoudimMB

The trigger is usually reaching a dose that exceeds what their current concentration can deliver in a single syringe draw

When STING pathway is stimulated, IFNs and pro-inflammatory cytokines are produced via downstream IRF3 and NF-kB pathways to inhibit hepatitis virus replication, initiate the immune response, facilitate the oncogenesis and metastasis of HCC (122)