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Chiou WF, Lin LC, Chen CF (2004) Acteoside protects endothelial cells against free radical-induced oxidative stress

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They discovered that using modified nucleotides (m 5 C, m 6 A, m 5 U, s 2 U or pseudouridine) in IVT mRNA, ablates the activation of TLR3, TLR7, TLR8 and TLR9 leading to a significant reduction in the production of type I interferons (IFNs) and pro-inflammatory cytokines compared to unmodified IVT mRNA (Figure 3) [ / ) MEFs, the extent of translation of -modified mRNA was not different from that of unmodified mRNA

Institutional Review Board Statement The authors confirm that the ethical policies of the journal have been adhered to

(2023f, December 15)

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