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Searches used combinations of controlled vocabulary (e.g., MeSH where available) and free-text terms capturing (i) PF and related descriptors and (ii) DPN and closely related phenotypes (including painful diabetic neuropathy and diabetic polyneuropathy), supplemented by mechanism- and endpoint-related concepts (e.g., oxidative stress, neuroinflammation, Schwann cell/myelination, axonal integrity, microvascular dysfunction, and drug delivery)

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In the pre-processing stage, the data underwent unit variance scaling

Larriba, S

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However, inadequate NADPH production in cells with restricted glucose intake significantly augments actin cytoskeletal disulfide bonds, causing disruption in the actin network and intracellular disulfide hyperplasia