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Serious safety concerns (immune reactions, cancer risk)

J Physiol Pharmacol 60(Suppl 7):191196 Carvalho RDO, do Carmo FLR, de Oliveira Junior A, Langella P, Chatel JM, Bermudez-Humaran LG, Azevedo V, de Azevedo MS (2017) Use of wild type or recombinant lactic acid bacteria as an alternative treatment for gastrointestinal inflammatory diseases: a focus on inflammatory bowel diseases and mucositis

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Thoresen D, Wang W, Galls D, Guo R, Xu L, Pyle AM

Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes

It is notable that the beneficial effect of ARA 290 appears to be sustained for at least the 28-d follow-up period