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Description

One of the biggest contributing factors isstress

The elevated H 2 O 2 concentration drives the balance in the GPX and GR reactions towards GSSG thus lowering the [GSH]/[GSSG] ratio

Ruszkiewicz and Albrecht, 2015)

10.1002/hep.20466 Hepatology 29 BruntE

Springer, Boston, pp 227243 Lingappan K (2018) NF-B in oxidative stress

Proc Natl Acad Sci 110:1267912684 Fu M, Zhang W, Wu L, Yang G, Li H, Wang R (2012) Hydrogen sulfide (H 2 S) metabolism in mitochondria and its regulatory role in energy production