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Increased 12/15-lipoxygenase leads to widespread brain injury following global cerebral ischemia

J., Hoeksma, M., Reijngoud, D.-J

9 When a carnitine deficiency develops, long-chain fatty acids are not available for -oxidation and energy production, thereby causing excessive lipid accumulation in skeletal muscle, heart, and liver and ultimately, leading to cardiac myopathy and hepatomegaly

The result is enhanced cell migration, meaning repair cells can actually reach damaged tissue more efficiently

[22] Diphenhydramine acts as a reversible, competitive antagonist-and more precisely, an inverse agonist-at the histamine H receptor, thereby stabilizing the inactive receptor conformation and preventing histamine-mediated vasodilation, increased capillary permeability, and sensory nerve activation

Yan MM, Zhao H, Li ZR, Chow JW, Zhang Q, Qi YP, Wu SS, et al