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While taking a higher dosage is unlikely to be dangerous, 250-500 mg is plenty to get sufficient levels

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DOI: 10.1161/HYP.0000000000000065 Wimalasena K (2011): Vesicular Monoamine Transporters: Structure-Function, Pharmacology, and Medicinal Chemistry

One of the most dose-limiting of these is peripheral neuropathy, which occurs in a dose- and time-dependent manner (Ozols and Young, 1985)

Regarding safety, common adverse events of tofacitinib include herpes zoster infections, hypercholesterolemia, venous thromboembolism (VTE), and cardiovascular events

Rats were fed a control diet or the same diet supplemented with buthionine sulfoximine (BSO