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doi: 10.1016/S0022-510X(03)00004-2 115 Machado-SantosJSajiETroscherARPaunovicMLiblauRGabrielyGet al

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

At the molecular mechanism level, critical questions remain unanswered: the specific molecular interaction networks underlying NTFs-mediated mitochondrial regulation (e.g., the full spectrum of PGC-1 post-translational modifications, the selective recognition mechanism of NTFs-induced mitophagy) have not been fully elucidated, and heterogeneous responses at the single-cell level require further investigation

203 Glutamatergic excitotoxicity Glutamate is the main excitatory neurotransmitter of glutamatergic neurotransmission in the CNS