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Acknowledgements We thank all the researchers who have spent their time and effort in trying to understand the complexity of this issue, and we extend our apologies if we could not accommodate a particular work in this review because of space constraints

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14 Thus, the lowering effect of taurine on CCAAT/enhancer binding protein homologous protein, a marker of endoplasmic reticulum stress, in the study by Zulli et al 8 may simply have been attributed to the water solubility of intracellular taurine conjugates and may have had nothing to do with the methionine-taurine pathway