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Description

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

In GT- 1a, RZR is 10-fold more potent than velpatasvir (VEL), and it retains single-digit pM antiviral activity against RAVs (M28V+Q30R, M28T+T64A, L31M+H58P) selected by previous NS5A inhibitors, while velpatasvir is 10 time less potent against selected double mutants (M28V+Q30R, M28T+T64A)