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A five-year clinical trial in which 619 hemodialysis patients who received 2.5 mg of folic acid, 1 mg of vitamin B12, and 50 mg of vitamin B6 daily had significantly lower plasma levels of homocysteine

High Hcy is often linked to low levels of vitamins B6, B9, and B12 and affects about 5% of people, with higher risks in those with poor diets, older adults, men, and people in low-income countries