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Many of these compounds efficacy and safety remain incompletely and properly evaluated in humans, and continue to be used outside conventional medical frameworks, increasingly marketed with the language of longevity, optimization, and self-care

People use them as part of a weight loss or weight management plan in addition to a low-calorie diet and exercise routine

Patients should promptly inform their doctor if they experience persistent or severe symptoms

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Severe deficiency can cause irreversible nerve damage

Low body temperature (hypothermia) is also a warning, as it reflects severe impairment of the body's ability to regulate temperature