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The tretinoin in GHK-Cu/Estriol/Niacinamide/Tretinoin may cause a transient increase in irritation

ALCA, together with alpha-lipoic acid, was shown to improve mitochondrial energy metabolism and decrease oxidative stress leading to improved memory in aged rats [144, 145]

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Meanwhile, glutamate oxaloacetate transaminase 1 (GOT1) supports redox homeostasis by maintaining NADPH balance, and glutamate dehydrogenase 2 (GDH2) contributes to mitochondrial signaling that enhances apoptosis resistance [96,102-105]