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Yan LS, Zhang SF, Luo G, Cheng BC, Zhang C, Wang YW, et al

After 21 days, mice were randomized into four different experimental treatment groups: vehicle, cisplatin (4 mg kg 1 once per week for 1 week), RSL3 (50 mg kg 1 , two times per week for 2 weeks) and cisplatin in combination with RSL3

The most notorious function of mitochondria, which is to oxidize various nutrients such as fat and carbohydrate via a series of complex chemical reactions to create the basic energy unit ATP

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PARP inhibitors , including olaparib and niraparib , impair DNA repair in BRCA-mutated cells and are approved for ovarian, breast, pancreatic, and prostate cancers

In addition to thiosemicarbazone derivatives, thiosemicarbazide and its derivatives 378381 , 5-benzylidene(thio)barbiturate-beta-d-glycosides 382 , n -alkyl 383 , p -phenylene-bis, phenyl 384 , benzyl, p -xylidine-bis and p -pyridine dithiocarbamate sodium salts 385 , diethyldithiocarbamate, phenylthiourea 3 86 and other thiourea derivatives (Figure 12) such as methimazole, thiouracil, methylthiouracil, propylthiouracil, ambazone, and thioacetazone 387 have been identified as tyrosinase inhibitors