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Avoid repeated temperature changes

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[4] The peptide survives digestion long enough to act on the mucosa, but clears too rapidly to accumulate in systemic circulation

Rat amylin analogs with these affinity-enhancing mutations also significantly enhanced potency for calcitonin receptor activation by 5- to 11-fold compared to endogenous rat amylin and a clinical drug pramlintide (Figure 9D and Table 3)

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